CHEMILUMINESCENCE-BASED DETECTION OF BIOMARKERS IN INFECTIOUS DISEASES.
ABSTRACT
Chemiluminescence-based detection has emerged as a powerful tool for the identification and quantification of biomarkers in infectious diseases, offering sensitive, specific, and rapid diagnostic capabilities. This abstract highlights the significance of chemiluminescence-based detection in the field of infectious diseases, focusing on advancements in assay development, applications in biomarker detection, and the potential future directions of this technology. Infectious diseases pose significant global health challenges, necessitating the development of robust diagnostic methods for timely and accurate detection. Chemiluminescence-based detection methods, employing luminogenic substrates and catalysts, enable the sensitive and specific detection of biomarkers associated with infectious agents, including viruses, bacteria, and parasites. By harnessing the unique light-emitting properties of chemiluminescence reactions, researchers have achieved remarkable improvements in sensitivity and detection limits, facilitating early-stage identification of infectious diseases.
Chemiluminescence-based assays have been developed and optimized for the detection of a wide range of infectious disease biomarkers, including viral antigens, antibodies, nucleic acids, and metabolites. These assays offer several advantages, such as simplicity, versatility, and compatibility with high-throughput screening platforms. They have been successfully applied in the diagnosis and surveillance of various infectious diseases, including HIV, hepatitis, influenza, malaria, and emerging viral outbreaks. Chemiluminescence-based detection methods enable rapid and accurate identification of infectious agents, aiding in disease management, epidemiological studies, and infection control strategies.
The integration of chemiluminescence-based detection with innovative technologies has further enhanced its utility in infectious disease biomarker detection. For instance, the combination of chemiluminescence with microfluidic systems, nanomaterials, and point-of-care devices has enabled the development of portable and user-friendly diagnostic platforms. These advancements promote decentralized testing, particularly in resource-limited settings, facilitating early detection, monitoring treatment response, and improving patient outcomes.
Ongoing research and development efforts aim to expand the scope of chemiluminescence-based detection in infectious diseases. Integration with multiplexing techniques allows simultaneous detection of multiple biomarkers, enhancing diagnostic accuracy and efficiency. Additionally, the incorporation of molecular amplification strategies, such as isothermal amplification or nucleic acid amplification, amplifies the signal output, further improving sensitivity and enabling detection of low-abundance targets. The exploration of novel luminogenic substrates, catalysts, and detection modalities continues to drive the evolution of chemiluminescence-based detection, paving the way for future advancements in infectious disease diagnostics.
CHEMILUMINESCENCE-BASED DETECTION OF BIOMARKERS IN INFECTIOUS DISEASES, GET MORE CHEMICAL PATHOLOGY PROJECT TOPICS AND MATERIALS HERE.